Trials assessing parmacotherapeutic management of aggression in psychiatric patients: comparability with clinical practice.

نویسندگان

  • L E Goedhard
  • J J Stolker
  • H L I Nijman
  • T C G Egberts
  • E R Heerdink
چکیده

INTRODUCTION In a previous review of randomized controlled trials (RCTs) on the pharmacotherapeutic management of aggression, it was shown that there is only weak evidence of effectiveness. In the present study we aim to determine comparability of patients included in these RCTs and patients of psychiatric long-stay wards. METHODS Exclusion criteria that were used in at least 20% of the RCTs were applied to a sample of aggressive inpatients from clinical practice, in order to find what proportion of these patients would be eligible to participate in the reviewed, high quality RCTs. RESULTS Only 30% of aggressive psychiatric patients as seen in clinical practice would be eligible to participate in a typical randomized controlled trial based on the most frequently applied exclusion criteria. DISCUSSION The low comparability of patients included in RCTs with those seen in clinical practice may decrease the generalizability of the findings form RCTs to clinical practice.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Anger Management Training Using Workshop and Training Package Methods on the Aggression of Patients with Addiction

Background: Given the importance of anger controlling on addicts aggression at withdrawal beginning and their specific conditions, it is essential that different educational methods tailored to the content anger management to reduce aggression and control anger in the addicted people. Aim: This study aimed to compare the effect of anger management training using workshop and training package me...

متن کامل

Validation of Instruments for Assessing Drug Safety Management During the Conduction of Clinical Trials

Background The management of drug safety with the collection of reliable safety data during the conduction of clinical trials conduct is essential for the registry and marketing of products. The systematic evaluation of this process, based on objective measures, requires the application of quality instruments. This study was aimed to design and validate eight instruments through the components ...

متن کامل

Prevalence and correlates of aggression among psychiatric in-patients at Jos University Teaching Hospital.

OBJECTIVE The study was designed to determine the prevalence of aggression and clinical factors associated with aggression among psychiatric in-patients at Jos University Teaching Hospital. This will help create a good knowledge base about management of these patients. MATERIALS AND METHODS All admitted psychiatric patients between December, 2005, and February, 2007, that met the ICD-10 crite...

متن کامل

Managing acutely aggressive or agitated people in a psychiatric setting: a survey in Lebanon

Background: Violent patients constitute 10% of all psychiatric admissions. Treatment options and clinical practice interventions vary across the globe and no survey of practice in a Middle Eastern setting exists. Surveying treatments in Lebanon will show treatment interventions used in this part of the world and, most importantly, provide the treatment options that could potentially be used for...

متن کامل

Distress Tolerance, Impulsivity and Aggression: the Role of Emotional Dysregulation and Reward Sensitivity in Individuals with Borderline Personality Disorder Features

Objective: Borderline personality disorder is one of the most severe psychiatric disorders. The purpose of this study was to predict distress tolerance, impulsivity and aggression based on emotional dysregulation and reward sensitivity among individuals with borderline personality disorder features. Methods: The statistical population of the present research was undergraduate students of Shahi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Pharmacopsychiatry

دوره 43 6  شماره 

صفحات  -

تاریخ انتشار 2010